| Heim | Resultat | Gast | Stadion |
| Sevilla F. C. | 1 – 0 | Real Sociedad | Sánchez Pizjuán |
| Girona F. C. | 1 – 4 | S. D. Eibar | Montilivi |
| Athletic Club | 2 – 0 | Real Betis Europa League asegurada | San Mamés |
| R. C. Celta de Vigo | 1 – 1 | R. C. Deportivo de La Coruña | Balaídos |
| Villarreal C. F. | 1 – 0 | Valencia C. F. Champions League asegurada | La Cerámica |
| Málaga C. F. | 0 – 3 | Deportivo Alavés | La Rosaleda |
| Atlético de Madrid | 0 – 2 | R. C. D. Español | Wanda Metropolitano |
| U. D. Las Palmas | 0 – 1 | Getafe C. F. | Gran Canaria |
| F. C. Barcelona | 2 – 2 | Real Madrid C. F. | Camp Nou |
| C. D. Leganés | 0 – 3 | Levante U. D. | Butarque |
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Usprungs-Bildmaterial:
Spain_location_map.svg: NordNordWestderivative work: Ottobdn (talk) - Spain_location_map.svg, CC BY-SA 3.0, https://commons.wikimedia.org/w/index.php?curid=15371900