| Heim | Resultat | Gast | Stadion |
| R. C. D. Español | 1 – 0 | Real Madrid C. F. | RCDE Stadium |
| Girona F. C. | 1 – 0 | R. C. Celta de Vigo | Montilivi |
| Athletic Club | 1 – 1 | Valencia C. F. | San Mamés |
| Málaga C. F. | 0 – 1 | Sevilla F. C. | La Rosaleda |
| Getafe C. F. | 3 – 0 | R. C. Deportivo de La Coruña | Alfonso Pérez |
| Atlético de Madrid | 4 – 0 | C. D. Leganés | Wanda Metropolitano |
| S. D. Eibar | 1 – 0 | Villarreal C. F. | Ipurúa |
| Real Betis | 0 – 0 | Real Sociedad | Villamarín |
| U. D. Las Palmas | 1 – 1 | F. C. Barcelona | Gran Canaria |
| Deportivo Alavés | 1 – 0 | Levante U. D. | Mendizorroza |
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Spain_location_map.svg: NordNordWestderivative work: Ottobdn (talk) - Spain_location_map.svg, CC BY-SA 3.0, https://commons.wikimedia.org/w/index.php?curid=15371900